Mike Lord and Lynne Roberts. For over 9 years he worked at EMBL developing and applying novel high-throughput imaging approaches to study protein localisation and membrane traffic. His lab currently applies high-throughput imaging technologies to study trafficking between the ER and Golgi complex, the internalisation pathways taken by synthetic nanoparticles on exposure to cells, and how cells responds to cellular exposure to nanomaterials and nanosurfaces. His lab also develops novel software tools for image analysis.
He has authored over 80 peer-reviewed articles, including articles in Nature Cell Biology and Nature Methods, and a number of book chapters. The internal organelles of mammalian cells provide the possibility of keeping proteins with different functions in separate locations.
This is achieved through membrane traffic, a process that uses vesicular and tubular membrane carriers to transport proteins between compartments in both the secretory and endocytic systems. My lab is interested in how these pathways are organised, and in defining the protein machinery that regulates the timing and specificity of trafficking steps.
We are also investigating the relationship between membrane traffic and cytoskeleton function. Knowledge of these cellular systems is important for understanding infection and disease, and also for improved drug delivery and biomaterial design. Dattr
Simpson JC; High content screening microscopy for the large-scale identification and functional characterisation of novel membrane traffic proteins. Knowledge of these cellular systems is important for understanding infection and disease, and also for improved drug delivery and biomaterial design.
Nature Communications , 7:
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